Speedball
A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because the opposing drugs can mask each other’s effects, increasing the chance of overdose, respiratory failure, or heart problems.
Author Destiny Bezrutczyk
Reviewer Kristen Fuller, MD
What Is A Speedball?
A speedball is a mixture of the illicit drugs heroin and cocaine. Typically, speedballing involves both substances being injected into the bloodstream via needles, but they are sometimes snorted together as well. Individuals who speedball claim to experience a more intense, longer lasting high than that experienced when taking either drug alone.
Heroin is a common illicit opioid (derived from morphine) that slows breathing and can lead to respiratory failure, especially when combined with another depressant, such as alcohol. Cocaine, a stimulant, has nearly the opposite effect (such as increased heart rate and energy, rapid breathing, etc). It is a common misconception that mixing heroin with cocaine will either balance or cancel out the negative side effects of heroin. In reality, combining these substances is more dangerous than using either alone because their negative effects can be amplified.
Mixing heroin and cocaine increases the risk of overdose or permanent damage to the body.
Speedballing is especially dangerous because it combines a stimulant (such as cocaine) with a depressant (such as heroin), forcing the body to handle opposing effects at the same time. Cocaine stimulates the nervous system and increases the body’s demand for oxygen, while heroin slows breathing and depresses vital functions. This “push-pull” effect strains the heart, lungs, and brain, and increases the risk of confusion, respiratory failure, or overdose. The danger is heightened because cocaine wears off more quickly than heroin, leading many people who speedball to inject more frequently, which further raises the risk of overdose and other complications.
Side Effects Of Speedballing
The side effects commonly associated with cocaine are anxiety, hypersensitivity, high blood pressure, and irregular or rapid heartbeat. Opioids like heroin are often linked to drowsiness and a slowed breathing rate. When combined, the side effects of speedballing primarily negatively impact the brain.
Combining cocaine and heroin is a potent cocktail with a very high risk of unpredictable side effects.
Common side effects of speedballing include:
- Confusion or incoherence
- Blurred vision
- Drowsiness
- Paranoia
- Mental impairment due to lack of sleep
- Uncontrollable movements
- Stupor
There are also long-term side effects of speedballing on the major organs of the body, including the lungs, heart, and liver. There are reports of individuals who experience manic episodes, paranoia, or depression after speedballing as well.
Even worse, speedballing creates a high risk of death. Potentially fatal side effects of speedballing include:
- Stroke
- Heart attack
- Aneurysm
- Respiratory failure
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Factors That Influence How Speedballing Impacts the User
There are many factors that influence how combining heroin and cocaine impacts the body. The same individual can use the same amount of the same drugs on different occasions and experience different effects each time. Some of these factors include:
- The drug itself: its purity, the amount used, frequency of prior use, whether it has been cut or mixed with other drugs, and how it is administered.
- The setting: who the user is with and where they are physically.
- The individual taking the drugs: their mood, personality, mental health, medical history, and individual biology.
The Dangers Of Mixing Drugs
The risk of respiratory failure is even more likely when speedballing due to differences in how long cocaine and heroin affect the body. The euphoric effects of cocaine wear off faster than heroin. When this happens, the full respiratory-impairing effects of heroin hit the body.
Additionally, the combination of cocaine and heroin can strengthen the effects of each, often leading to overdose.
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Speedball-Related Overdoses
During the second wave of the opioid epidemic, the spread of illicitly manufactured fentanyl, a synthetic opioid up to 100 times stronger than morphine and about 50 times stronger than heroin, led to a sharp rise in overdose deaths. While some people knowingly sought fentanyl for its potency, many others were unaware that it had been mixed into counterfeit pills (such as fake oxycodone tablets) or heroin. This hidden presence significantly increased the risk of fatal overdoses.
Data collected from 37 states and DC shows that 47% of drug overdose deaths in 2023 involved both opioids and stimulants.
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